The Centre for Health Protection (CHP) of Department of Health (DH) conducted a ceremony to kick-off the Hand Hygiene Campaign 2014 on 29 April 2014. The ceremony unveiled a series of promotional and educational activities in collaboration with various stakeholders. The campaign aims to establish defense against antimicrobial resistance (AMR) at multiple levels and proper hand hygiene is of prime importance. Hospitals from public and private sectors will join hands in hand hygiene promotion. The campaign promotion is not limited to hospitals but also to other healthcare settings including clinics and long-term care facilities (LTCFs). A series of newly developed, tailored-made promotional materials will be launched. This Campaign will last from Hand Hygiene Awareness Day on 5 May till the Antibiotic Awareness Day 2014 in November.